50g Creatine Monohydrate Powder Relax Lines Wrinkles Firming Tight Skin Free Kit Creatine (a-methyl guanidine-acetic acid) is a natural derivative of the amino acids: arginine, methionine and glycine. Topical use rate: 1% "Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective anti-wrinkle and anti-sagging efficacy in male subjects." (They were probably studying mostly male subjects because they focused on body building.) https://www.ncbi.nlm.nih.gov/pubmed/22151935 Works well with CoQ10 aka Ubiquinol, too. Creatine is a small peptide found primarily in muscle cells. It is produced inside the body from the amino acids glycine and arginine, and it is widely distributed to tissues with high energy demands, such as the brain and muscles. About 95% of the body?s creatine is stored in skeletal muscle, but it is also found in small amounts in the liver, kidneys, and testes. On average, the body produces approximately 1 gram of creatine per day in young adults [7-8], while the rest is obtained through diet. As we age, the amount of creatine our bodies produce declines. Creatine is naturally occurring in many foods, particularly animal protein, such as meat and fish. Applying a cream containing creatine daily for six weeks reduced skin sag and wrinkles in men in one study; and separate research found that a cream with creatine and folic acid improved sun damage and reduced wrinkles. Preliminary research suggests that a cream containing creatine and other ingredients applied to the face every day for six weeks might reduce skin sag and wrinkles in men. Another study suggests that a cream containing creatine and folic acid improves sun damage and reduces wrinkles.